BoltzGen

Not sure how to set this up? — Tutorial

Name

Allowed: a-z, 0-9, _ and -. Must start and end with a letter or digit.

Protocol

If unsure, start with protein-anything.

Num designs

Budget

Entities

Upload a target structure, then optionally add designed binders and ligands.

Stages

Design, affinity, fold, inverse fold

Design stage

Recycling steps

Sampling steps

Diffusion samples

Affinity stage

Recycling steps

Sampling steps

Diffusion samples

Fold stage

Recycling steps

Sampling steps

Diffusion samples

Inverse fold stage

Recycling steps

Sampling steps

Diffusion samples

Noise

Defaults are set for a balanced run. Adjust only if you know what you want.

Filtering

Alpha, biased filtering, extra metric rules

Alpha

Filter biased

Refolding RMSD threshold

Additional filters

Constraints

Covalent bonds, total length

Bond constraints reference entity chain IDs (A, B, C...) and residue/atom identifiers.

# API example will render here

Execute